Postdoctoral fellowship at the University of Pennsylvania
The Beltran lab within the Division of Experimental Retinal Therapies, School of Veterinary Medicine, at the University of Pennsylvania is seeking exceptional candidates for a Postdoctoral fellowship in the field of neuroinflammation. Gene therapies for many different retinopathies have taken center stage in recent years with one FDA approved gene therapy in the market and over 30 other retinal gene therapies in clinical trials. Concern has also grown for gene therapy associated inflammation and its impact on long-term patient outcomes. This research project will focus on an in-depth understanding of AAV-mediated inflammation pathways and immune responses in large animal models and development of targeted mitigation strategies to reduce the possibility of persistent chronic inflammation post retinal gene therapy administration. Using transcriptomic and proteomic approaches, the goal will be to differentiate the pathways and molecules involved in disease-associated chronic retinal inflammation observed in most retinopathies, and those emerging post-gene therapy.
PhD in biological sciences (such as: Neurosciences, Immunology, Cell and Molecular Biology).
We encourage applicants with prior experience in transcriptomic and proteomic data analysis. Experience in the field of immunology and a thorough understanding of basic cell and molecular biology techniques will be an advantage. Experience working with animals or in the field of AAV gene therapy preferred but is not necessary.
Interested applicants should submit their CV, cover letter and 3 references to Dr. Raghavi Sudharsan at raghavi@vet.upenn.edu